The two different forms of CoQ10 are Ubiquinone and Ubiquinol (actually there is a third semi-ubiquinone which is an intermediary between ubiquinine and ubiquinol) Both forms are present in the body. Ubiquinone is the oxidized form and is very stable; it's role in the body is for energy production. Ubiquinol is the reduced form and is very unstable; it's role in the body is as an antioxidant; it does not participate in energy production.. Through a redox system the body can change ubiquinol to ubiquinone and vice versa depending on the body needs. There has been some marketing recently from a well known CoQ10 company that would indicate that ubiquinol is better absorbed that ubiquinone. However, that has been disproven. Ubiquinol products contain crystals and the body cannot absorb a crystal. Not only that but when ubiquinol is ingested and exposed to oxygen in the contents of the stomach, it becomes ubiquinone. Our CytoMed CoQLIFE is a ubiquinone CoQ10 product. It has the highest absorption of any CoQ10 product available. It is in a tri-lipid formula: lipid one dissolves the crystals into single molecules; the second lipid prevents recrystalization; and the third lipid is a monoglyceride that carries the CoQ through the microvillus in the small intestine into the lymph system and eventually into the systemic circulation and then into the cell membranes of every cell.
I am sorry that the misinformation has gotten into thePWSwebsite. Dr. Bill has been a CoQ10 researcher for over 40 years, and is considered one of the world's experts. Thank you for asking us about this issue. Dr. Judy has worked with several families with children with PWS. It has been his very favorite research.
I can tell you that some ubiquinol products are absorbed better than some ubiquinone products, but that is because the lipid based ubiquinol was compared to a dry powder ubiquinone (full of crystals). When ubiquinol is compared to our tri-lipid formula, it fails the test. CytoMed CoQLIFE is 800% better absorbed than dry powder formulas, and 300% better absorbed than other softgel and lipid based products. Seven different institutions have NOT been able to reproduce the high absorption data of this Company X's ubiquinol
One of the major problems with children with PWS is the urgent need to produce energy. That's why Dr. Judy and our whole team worked so hard to develop a product that had such high absorption. I can tell you that to develop the CoQLIFE formula has taken over 7 years and 67 generations of formulas before this final formula was developed. It was no mere coincidence but intense work. It has a world wide patent pending. It is one of a kind....
Over the past couple of months ,we have received some inquiries asking if our CoQLIFE is the oxidized ubiquinone or the reduced ubiquinol; the difference being two hydrogen ions. Our CoQLIFE is ubiquinone. And here are the reasons Dr. Judy prefers to use ubiquinone rather than ubiquinol:
1.Ubiquinone has been researched for more than 40 years. There are literally 10’s of thousands of studies using ubiquinone. Commercially available ubiquinol is relatively new and has been researched for less than 5 years. There remain several unresolved questions as to its stability, absorption, and safety.
2.The CoQ10 synthesized in the human body is ubiquinone. It is true that the greater percent of CoQ10 is converted from ubiquinone to ubiquinol to be used by the body cells as a potent antioxidant. (Ubiquinone is used for energy production.) However, in this conversion some essential biochemical changes occur. Ubiquinone is first converted to a semiquinone and then to ubiquinol. When ubiquinol is ingested rather than ubiquinone this important step is bypassed and we really don’t yet know what the ramification of skipping this step may be.
3.Ubiquinol costs three times more than ubiquinone. There are a very small percentage of people worldwide who have a genetic aberration that causes them to be unable to absorb ubiquinone and, for them, ubiquinol appears to be a viable alternative. But the majority of people can absorb CoQ10, when it is properly prepared (single molecules in a lipid carrier). In addition, there is no proof that ubiquinol is absorbed as ubiquinol. In the presence of oxygen, ubiquinol is converted to ubiquinone. There is oxygen in the stomach so when the ubiquinone enters the digestive tract it may very well be converted to ubiquinone. So why pay more for unstable ubiquinol?
4.Some of you may have heard that the 15-year study using CoQ10 in elderly, more severe Parkinson’s patients had a negative result. In other words they did not prove that CoQ10 ameliorated the debilitating symptoms of Parkinson’s disease. However, it was found that when used in younger, less severe cases of Parkinson’s, CoQ10 did have a benefit in that it reduced or eliminated the symptoms. The reason for the failure of the study in elderly patients may be due to the poor quality CoQ10 product used. They used dry powder, crystal CoQ10 and were not able to raise the blood levels to a therapeutic level. To be therapeutic CoQ10 blood levels need to be above 3.5 ug/ml; in this study, using 1600 to 2400 mg of CoQ10, they were not able to raise the blood levels above 3.0 ug/ml. We are currently using 250 mg of CoQLIFE in these types of patients and are able to raise the blood levels above 4.4 ug/ml. We have been advising the NIH sponsors for 10 years that they are using the wrong CoQ10 formulation and therefore are not able to raise the blood levels to an adequate level for treatment of advanced Parkinson’s.
5.In the body ubiquinol is an antioxidant, one of many, and not necessarily the most potent antioxidant. Ubiquinone is used for cellular energy of every cell in the body, and there is nothing that can replace its important role in energy production. This is of particular significance to anyone taking CoQ10 for diseases that result from low energy: heart failure, Parkinson’s, Prader-Willi syndrome, cancer, immune diseases, diabetes, obesity, migraine headaches, gingivitis, myopathies secondary to taking Statin drugs for high cholesterol, muscular dystrophy, and other age related degenerative diseases.
William V. Judy, PhD
A interesting inquiry came through our contact page the other day. One of our clients heard through a list serve that ubiquinol is much better absorbed than ubiquinone. You may have read this too. Please read the information below that clarifies this issue.